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试剂描述:

产品名称:Mycalolide B

产品别名:4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C

CAS号:122752-21-0

英文别名:Mycalolide B

分子量:1027.16

分子式:C₅₂H₇₄N₄O₁₇

纯度:≥98%

外观:见爱必信官网

保存方法:Store at -20° C

描述:Mycalolide B has been shown to inhibit actin polymerization (IC₅₀=10-50 nM) with a different mechanism of action from cytochalasin D. It suppresses actin-activated myosin Mg²⁺-ATPase activity without changing myosin light chain phosphorylation resulting in inhibition of smooth muscle contractions. Mycalolide B depolymerizes F-actin at differing concentrations by nibbling and forms a 1:1 complex with G-actin. Mycalolide B, at a concentration of 3 μM, abolished both ADP (10 μM)- and collagen (3 μg/ml)-induced platelet aggregation in vitro.

应用:A novel and specific actomyosin ATPase inhibitor

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