爱必信(上海)生物科技有限公司
欢迎联系我们! 服务热线: 021-38015121
 
 
产品展厅
您当前的位置: 网站首页 > 产品展厅 >米格鲁他
米格鲁他
  • 品牌:爱必信(absin)
  • 产地:上海
  • 货号:abs42023133
  • cas:72599-27-0
  • 价格: ¥1529/瓶
  • 发布日期: 2023-07-20
  • 更新日期: 2024-06-20
产品详请
产地 上海
品牌 爱必信(absin)
货号 abs42023133
用途 Inhibits glucosylceramide synthase and α-glucosidase I and II without overt pathology
CAS编号 72599-27-0
纯度 0.98%
规格 5mg
是否进口

公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!

 

试剂描述:

产品名称:米格鲁他

产品别名:

CAS号:72599-27-0

英文别名:米格鲁他

分子量:255.74

分子式:C10H21NO4?HCl

纯度:98%

外观:见爱必信官网

保存方法:Store at -20° C

描述:N-Butyldeoxynojirimycin·HCl is a novel inhibitor of UGCG (glucosylceramide synthase) as well as Glucosidase I and II (α-glucosidase I and II). The compound has been shown to inhibit glucosylceramide synthase without ceramide accumulation and cell death. When administered to young mice the compound reduced glycosphingolipid production 50%-70% in the liver and lymphoid organs without any overt pathology. It is a potent inhibitor of HIV virus replication and syncytium formation in vitro. The compound has been observed to restore cAMP-activated chloride currents in epithelial cystic fibrosis cells through prevented interaction among calnexin and delF508-CFTR. In a mice model for Tay Sachs disease, mice exposed to N-Butyldeoxynojirimycin·HCl limited the biosynthesis of GM2 thus preventing accumulation of GM2 in the brain and glycosphingolipids. This action markedly reduced the number of storage neurons and gangliosides per cell. N-Butyldeoxynojirimycin·HCl has also rescued trafficking-deficient F508del-CTFR in human airway epithelial cells via inhibition of ER-glucosidases I and II. Also has broad spectrum antiviral activity.

应用:Inhibits glucosylceramide synthase and α-glucosidase I and II without overt pathology

产品信息订购:

  产品货号   产品名称   规格 价格 大包装及货期
  abs42023133   米格鲁他   25mg   5976.00   立即咨询
  abs42023133   米格鲁他   5mg   1529.00   立即咨询

产品更多信息请进入爱必信(absin)商城查看》》》



absin,您身边的科研百宝箱
专业提供试剂、耗材、仪器,在线订购,7*24h全国发货,方便快捷!

联系方式
手机:18438616290