L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Shown to preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ).

A DNA ligase I, III and IV inhibitor

≥95%

Store at -20° C

Solid

n20D ~1.73 (Predicted)

DNA ligase I: IC50 = 5 μM; DNA ligase III : IC50 = 9 μM; DNA ligase IV : IC50 = 5 μM

DNA ligase I: Ki= 5 μM

Soluble in DMSO (100 mM).

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