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试剂描述:

产品名称:8-羟基-7-(6-硫-2-萘氮杂)-5-喹啉磺酸

产品别名:

CAS号:56990-57-9

英文别名:8-羟基-7-(6-硫-2-萘氮杂)-5-喹啉磺酸

分子量:459.45

分子式:C₁₉H₁₃N₃O₇S₂

纯度:>98%

外观:见爱必信官网

保存方法:Desiccate at 4° C

描述:NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1). IC₅₀ values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR, respectively. NSC 87877 has also been shown to inhibit EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability and/or proliferation.

应用:A potent inhibitor of shp2 and shp1 protein tyrosine phosphatases

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