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试剂描述:

产品名称:8-氯-1-(2,4-二氯苯基)-N-(1-哌啶基)-1,4,5,6-四氢苯并[6,7]环庚并[1,2-c]吡唑-3-甲酰胺

产品别名:

CAS号:494844-07-4

英文别名:8-氯-1-(2,4-二氯苯基)-N-(1-哌啶基)-1,4,5,6-四氢苯并[6,7]环庚并[1,2-c]吡唑-3-甲酰胺

分子量:489.82

分子式:C₂₄H₂₃Cl₃N₄O

纯度:≥98%

外观:见爱必信官网

保存方法:Store at -20° C

描述:NESS 0327 is an extremely potent cannabinoid receptor antagonist, selective for the CB1 receptor (K_i = 0.35 pM) over the CB2 receptor (K_i = 21 nM). It is more potent and selective for the CB1 receptor than rimonabant , one of the first discovered CB receptor antagonists. At nM concentrations, NESS 0327 competitively inhibits the binding of the synthetic CB agonist WIN 55,212-2 in isolated rat cerebella membranes and murine vas deferens. Unlike rimonabant, NESS 0327 does not act as a CB1 receptor inverse agonist at higher concentrations, nor does it produce any physiological effects of its own.

应用:A potent, selective CB1 receptor antagonist

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