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产品展厅
NNC 05-2090 hydrochloride;184845-43-0
  • 品牌:爱必信(absin)
  • 产地:上海
  • 货号:abs42023725
  • cas:184845-43-0
  • 价格: ¥2716/瓶
  • 发布日期: 2023-07-20
  • 更新日期: 2024-02-21
产品详请
产地 上海
品牌 爱必信(absin)
货号 abs42023725
用途 A GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters
产品规格 10mg;50mg
CAS编号 184845-43-0
纯度 ≥99%%
是否进口
    产品描述
描述
NNC 05-2090 hydrochloride is a GABA uptake inhibitor; displays moderate selectivity for BGT-1 (mGAT-2) transporters. GABA transporters belong to the solute carrier family 6 (SLC6) and are sodium- and chlorde-dependent members that mediate the rapid removal of GABA. NNC 05-2090 hydrochloride also displays affinity at α1- and D2-receptors (IC50 values are 266 and 1632 nM respectively). NNC 05-2090 hydrochloride is an inhibitor of GABA T-1, GABA T-2 and GABA T-3.
应用
A GABA uptake inhibitor displaying selectivity for BGT-1 (mGAT-2) transporters
纯度
≥99%
储存/保存方法
Desiccate at room temperature
形态
Solid
    基本信息
沸点
643.1° C at 760 mmHg (Predicted)
折射率
n20D ~1.62 (Predicted)
Ki 数据
BGT-1: Ki= 1.4 μM (human); GABA T-3: Ki= 15 μM (human); GABA T-1: Ki= 19 μM (human); GABA T-2: Ki= 41 μM (human)
可溶性/溶解性
Soluble in DMSO (100 mM), and ethanol (13 mM).
MDL
MFCD00952020
PubChem CID
18782760

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