NNGH is a cell-permeable and potent inhibitor of MMP-3. Alternate names include MMP-3 Inhibitor II and N-Isobutyl-N-(4-methoxyphenylsufonyl)-glycylhydroxamic Acid. NNGH may also demonstrate inhibition of MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12 (metalloelastase), MMP-13, MT-MMP-1 (MMP-14), and MMP-20.

A potent and cell-permeable inhibitor of MMP-3

≥98%

Store at room temperature

Solid

~1.3 g/cm3 (Predicted)

219.36° C (Predicted)

514.48° C (Predicted)

MMP2: IC50 = 0.01 μM; ADAM17: IC50 = 2.3 μM (human); MMP1: IC50 = 0.3 μM; MMP14: IC50 = 0.01 μM (human)

stromelysin-1 (MMP-3): Ki= 0.13 μM (human); MMP1: Ki= 0.17 μM; MMP8: Ki= 0.01 μM; MMP12: Ki= 4.3 nM

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