产品描述：

AZ13705339 is a highly potent and selective PAK1 inhibitor with IC50s of 0.33 nM and 59 nM for PAK1 and pPAK1, respectively. AZ13705339 has binding affinities to PAK1 and PAK2, with Kds of 0.28 nM and 0.32 nM, respectively. AZ13705339 can be used in the research of cancers.

储存/保存方法：

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

溶解性：DMSO : 250 mg/mL (396.98 mM; Need ultrasonic)

靶点：PAK1；PAK2

In vitro(体外研究)：

AZ13705339 (1 μM) inhibits αIgM-controlled adhesion and not PMA-induced adhesion in Namalwa cells.
AZ13705339 (300 nM, 30 min) prevents Siglec-8 engagement-induced eosinophil death.

In vivo(体内研究)：

AZ13705339 (100 mg/kg, P.O.) has moderate clearance and oral Cmax of 7.7 μM in rats.

分子结构图：